We develop a finite-sample, design-based theory for random forests in which each tree is a randomized conditional predictor acting on fixed covariates and the forest is their Monte Carlo average. An exact variance identity separates Monte Carlo error from a covariance floor that persists under infinite aggregation. The floor arises through two mechanisms: observation reuse, where the same training outcomes receive weight across multiple trees, and partition alignment, where independently generated trees discover similar conditional prediction rules. We prove the floor is strictly positive under minimal conditions and show that alignment persists even when sample splitting eliminates observation overlap entirely. We introduce procedure-aligned synthetic resampling (PASR) to estimate the covariance floor, decomposing the total prediction uncertainty of a deployed forest into interpretable components. For continuous outcomes, resulting prediction intervals achieve nominal coverage with a theoretically guaranteed conservative bias direction. For classification forests, the PASR estimator is asymptotically unbiased, providing the first pointwise confidence intervals for predicted conditional probabilities from a deployed forest. Nominal coverage is maintained across a range of design configurations for both outcome types, including high-dimensional settings. The underlying theory extends to any tree-based ensemble with an exchangeable tree-generating mechanism.

People Who Say They're Experiencing AI Psychosis Beg the FTC for Help The Federal Trade Commission received 200 complaints mentioning ChatGPT between November 2022 and August 2025. Several attributed delusions, paranoia, and spiritual crises to the chatbot. On March 13, a woman from Salt Lake City, Utah called the Federal Trade Commission to file a complaint against OpenAI's ChatGPT. She claimed to be acting "on behalf of her son, who was experiencing a delusional breakdown." "The consumer's son has been interacting with an AI chatbot called ChatGPT, which is advising him not to take his prescribed medication and telling him that his parents are dangerous," reads the FTC's summary of the call.

Objective: Electronic health records (EHR) data are prone to missingness and errors. Previously, we devised an "enriched" chart review protocol where a "roadmap" of auxiliary diagnoses (anchors) was used to recover missing values in EHR data (e.g., a diagnosis of impaired glycemic control might imply that a missing hemoglobin A1c value would be considered unhealthy). Still, chart reviews are expensive and time-intensive, which limits the number of patients whose data can be reviewed. Now, we investigate the accuracy and scalability of a roadmap-driven algorithm, based on ICD-10 codes (International Classification of Diseases, 10th revision), to mimic expert chart reviews and recover missing values. Materials and Methods: In addition to the clinicians' original roadmap from our previous work, we consider new versions that were iteratively refined using large language models (LLM) in conjunction with clinical expertise to expand the list of auxiliary diagnoses. Using chart reviews for 100 patients from the EHR at an extensive learning health system, we examine algorithm performance with different roadmaps. Using the larger study of $1000$ patients, we applied the final algorithm, which used a roadmap with clinician-approved additions from the LLM. Results: The algorithm recovered as much, if not more, missing data as the expert chart reviewers, depending on the roadmap. Discussion: Clinically-driven algorithms (enhanced by LLM) can recover missing EHR data with similar accuracy to chart reviews and can feasibly be applied to large samples. Extending them to monitor other dimensions of data quality (e.g., plausability) is a promising future direction.

This study presents an AI-driven pipeline for automated retinal segmentation and thickness analysis in diabetic retinopathy (DR) using SD-OCT imaging. A deep neural network was trained to segment ten retinal layers, intra-retinal fluid, and hyperreflective foci (HRF), with performance evaluated across multiple architectures. SwinUNETR achieved the highest segmentation accuracy, while VM-Unet excelled in specific layers. Analysis revealed distinct thickness variations between NPDR and PDR, with correlations between layer thickness and visual acuity. The proposed method enhances DR assessment by reducing manual annotation effort and providing clinically relevant thickness maps for disease monitoring and treatment planning.

This work suggests faster and space-efficient index construction algorithms for LSH for Euclidean distance (\textit{a.k.a.}~\ELSH) and cosine similarity (\textit{a.k.a.}~\SRP). The index construction step of these LSHs relies on grouping data points into several bins of hash tables based on their hashcode. To generate an $m$-dimensional hashcode of the $d$-dimensional data point, these LSHs first project the data point onto a $d$-dimensional random Gaussian vector and then discretise the resulting inner product. The time and space complexity of both \ELSH~and \SRP~for computing an $m$-sized hashcode of a $d$-dimensional vector is $O(md)$, which becomes impractical for large values of $m$ and $d$. To overcome this problem, we propose two alternative LSH hashcode generation algorithms both for Euclidean distance and cosine similarity, namely, \CSELSH, \HCSELSH~and \CSSRP, \HCSSRP, respectively. \CSELSH~and \CSSRP~are based on count sketch \cite{count_sketch} and \HCSELSH~and \HCSSRP~utilize higher-order count sketch \cite{shi2019higher}. These proposals significantly reduce the hashcode computation time from $O(md)$ to $O(d)$. Additionally, both \CSELSH~and \CSSRP~reduce the space complexity from $O(md)$ to $O(d)$; ~and \HCSELSH, \HCSSRP~ reduce the space complexity from $O(md)$ to $O(N \sqrt[N]{d})$ respectively, where $N\geq 1$ denotes the size of the input/reshaped tensor. Our proposals are backed by strong mathematical guarantees, and we validate their performance through simulations on various real-world datasets.

Statistical topic modeling is widely used in political science to study text. Researchers examine documents of varying lengths, from tweets to speeches. There is ongoing debate on how document length affects the interpretability of topic models. We investigate the effects of aggregating short documents into larger ones based on natural units that partition the corpus. In our study, we analyze one million tweets by U.S. state legislators from April 2016 to September 2020. We find that for documents aggregated at the account level, topics are more associated with individual states than when using individual tweets. This finding is replicated with Wikipedia pages aggregated by birth cities, showing how document definitions can impact topic modeling results.

In the field of image-based drug discovery, capturing the phenotypic response of cells to various drug treatments and perturbations is a crucial step. However, existing methods require computationally extensive and complex multi-step procedures, which can introduce inefficiencies, limit generalizability, and increase potential errors. To address these challenges, we present PhenoProfiler, an innovative model designed to efficiently and effectively extract morphological representations, enabling the elucidation of phenotypic changes induced by treatments. PhenoProfiler is designed as an end-to-end tool that processes whole-slide multi-channel images directly into low-dimensional quantitative representations, eliminating the extensive computational steps required by existing methods. It also includes a multi-objective learning module to enhance robustness, accuracy, and generalization in morphological representation learning. PhenoProfiler is rigorously evaluated on large-scale publicly available datasets, including over 230,000 whole-slide multi-channel images in end-to-end scenarios and more than 8.42 million single-cell images in non-end-to-end settings. Across these benchmarks, PhenoProfiler consistently outperforms state-of-the-art methods by up to 20%, demonstrating substantial improvements in both accuracy and robustness. Furthermore, PhenoProfiler uses a tailored phenotype correction strategy to emphasize relative phenotypic changes under treatments, facilitating the detection of biologically meaningful signals. UMAP visualizations of treatment profiles demonstrate PhenoProfiler ability to effectively cluster treatments with similar biological annotations, thereby enhancing interpretability. These findings establish PhenoProfiler as a scalable, generalizable, and robust tool for phenotypic learning.

Reinforcement learning (RL) has shown great promise in simulated environments, such as games, where failures have minimal consequences. However, the deployment of RL agents in real-world systems such as autonomous vehicles, robotics, UAVs, and medical devices demands a higher level of safety and transparency, particularly when facing adversarial threats. Safe RL algorithms have been developed to address these concerns by optimizing both task performance and safety constraints. However, errors are inevitable, and when they occur, it is essential that the RL agents can also explain their actions to human operators. This makes trust in the safety mechanisms of RL systems crucial for effective deployment. Explainability plays a key role in building this trust by providing clear, actionable insights into the agent's decision-making process, ensuring that safety-critical decisions are well understood. While machine learning (ML) has seen significant advances in interpretability and visualization, explainability methods for RL remain limited. Current tools fail to address the dynamic, sequential nature of RL and its needs to balance task performance with safety constraints over time. The re-purposing of traditional ML methods, such as saliency maps, is inadequate for safety-critical RL applications where mistakes can result in severe consequences. To bridge this gap, we propose xSRL, a framework that integrates both local and global explanations to provide a comprehensive understanding of RL agents' behavior. xSRL also enables developers to identify policy vulnerabilities through adversarial attacks, offering tools to debug and patch agents without retraining. Our experiments and user studies demonstrate xSRL's effectiveness in increasing safety in RL systems, making them more reliable and trustworthy for real-world deployment. Code is available at https://github.com/risal-shefin/xSRL.

Radio remains a pervasive medium for mass information dissemination, with AM/FM stations reaching more Americans than either smartphone-based social networking or live television. Increasingly, radio broadcasts are also streamed online and accessed over the Internet. We present WavePulse, a framework that records, documents, and analyzes radio content in real-time. While our framework is generally applicable, we showcase the efficacy of WavePulse in a collaborative project with a team of political scientists focusing on the 2024 Presidential Elections. We use WavePulse to monitor livestreams of 396 news radio stations over a period of three months, processing close to 500,000 hours of audio streams. These streams were converted into time-stamped, diarized transcripts and analyzed to track answer key political science questions at both the national and state levels. Our analysis revealed how local issues interacted with national trends, providing insights into information flow. Our results demonstrate WavePulse's efficacy in capturing and analyzing content from radio livestreams sourced from the Web. Code and dataset can be accessed at \url{https://wave-pulse.io}.

Due to the large size and lack of fine-grained annotation, Whole Slide Images (WSIs) analysis is commonly approached as a Multiple Instance Learning (MIL) problem. However, previous studies only learn from training data, posing a stark contrast to how human clinicians teach each other and reason about histopathologic entities and factors. Here we present a novel knowledge concept-based MIL framework, named ConcepPath to fill this gap. Specifically, ConcepPath utilizes GPT-4 to induce reliable diseasespecific human expert concepts from medical literature, and incorporate them with a group of purely learnable concepts to extract complementary knowledge from training data. In ConcepPath, WSIs are aligned to these linguistic knowledge concepts by utilizing pathology vision-language model as the basic building component. In the application of lung cancer subtyping, breast cancer HER2 scoring, and gastric cancer immunotherapy-sensitive subtyping task, ConcepPath significantly outperformed previous SOTA methods which lack the guidance of human expert knowledge.